DRC Certified Free of Dracunculiasis Transmission by WHO and other NTD News

This news roundup is a collection of headlines and other items on neglected tropical diseases, and does not reflect the work or the views of the Coalition for Operational Research on Neglected Tropical Diseases or the Neglected Tropical Diseases Support Center.


Photo Credit: Community engagement meeting in Kigoma DC discussing the feasibility of an integrated delivery model for arpraziquantel in the United Republic of Tanzania, NIMR/Kazyoba

Lymphatic filariasis

The Impact of Mass Drug Administration on Lymphatic Filariasis

Isaac Frimpong Aboagye and Yvonne Abena Afadua Addison, Journal of Tropical Medicine

Three years of MDA implementation were observed to have microfilaria prevalence reductions (88.54% to 98.66%) comparable to those of studies that implemented MDA for five to 10 years (≥5 years, 79.23% to 98.26%). Inadequate community understanding of and participation in the LF MDA programme are major drawbacks to its effective implementation. The implementation of MDA that incorporates community participation, incentivisation, education, and training strategies has the potential of increasing MDA coverage and compliance, thereby interrupting parasite transmission and reducing microfilarial prevalence to levels that warrant LF elimination.

Knowledge and participation in mass drug administration against lymphatic filariasis and soil-transmitted helminth infections among the community members in Dar es Salaam, Tanzania

Diana A Ngunyali et al., Transactions of The Royal Society of Tropical Medicine and Hygiene

This study found that the community has average knowledge and poor participation in MDA against LF and STHIs. Community sensitization is recommended to increase the participation of the community.


Ugandan Community Thrives in Absence of Disease

The Carter Center

After 28 years of treatments with Mectizan® (donated by Merck & Co., Inc., Rahway, New Jersey), the entire Madi-Mid North area, which includes Moyo, has reached a stage where experts suspect that transmission of river blindness is interrupted, a major step toward eventual elimination. . .The decline of river blindness has changed everything, Matalocu said. Crops can be planted near the fast-flowing rivers and streams now; people are healthier and more productive; children can go to school instead of staying home to help blinded family members.


Precision and geographical prevalence mapping of schistosomiasis and soil-transmitted helminthiasis among school-aged children in selected districts of north-western Tanzania

Humphrey D. Mazigo et al., Parasites & Vectors

The data reported here show that schistosomiasis and STH are widely distributed around Lake Victoria. In most of the schools where schistosomiasis and STH occurred the transmission thresholds were low. These data are important and need to be taken into consideration when decisions are made on the implementation of the next round of mass chemotherapies for schistosomiasis and STH in Tanzania.

Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity using latent class analysis

Silvia Gonçalves Mesquita et al., Frontiers in Microbiology

We showed that it is possible to achieve high specificity and sensitivity rates with lower costs by combining serological and NAATs tests, which would assist in the decision-making process for appropriate allocation of public funding aiming to achieve the WHO target of eliminating schistosomiasis as a public health problem by 2030.

Cross-Continental YouthMappers Action to Fight Schistosomiasis Transmission in Senegal

Michael Montani et al., Sustainable Development Goals Series

The authors detail the design of an innovative and cooperative approach to ground truthing geospatial data through cross-continental YouthMappers coordinated action. This effort provided key geographic information to design control actions and served as a powerful, active tool to disseminate awareness about the importance of neglected tropical diseases in remote regions of the planet in support of SDG 3 Good Health and Well-being and SDG 6 Clean Water and Sanitation.

Integrated delivery model for paediatric apraziquantel for schistosomiasis treatment: Preparatory work for its implementation in the United Republic of Tanzania

Corinne Merle and Branwen Hennig, TDR

The National Institute for Medical Research in the United Republic of Tanzania is working together with TDR, the World Health Organization (WHO), the Pediatric Praziquantel Consortium, and other key national and international stakeholders and Access and Delivery Partnership (ADP) partners to address gaps and challenges towards the roll-out of an exciting new paediatric schistosomiasis treatment, arpraziquantel.

Urogenital schistosomiasis in three different water access in the Senegal river basin: prevalence and monitoring praziquantel efficacy and re-infection levels

Bruno Senghor et al., BMC Infectious Diseases

Praziquantel has an impact on reducing the prevalence and intensity of urogenital schistosomiasis. However, in the Senegal river basin, S. haematobium remains a real health problem for children living in the villages near the irrigation canals, despite regular treatment, while prevalence is declining from those frequenting the river and the Lac de Guiers.

Praziquantel has an impact on reducing the prevalence and intensity of urogenital schistosomiasis. However, in the Senegal river basin, S. haematobium remains a real health problem for children living in the villages near the irrigation canals, despite re

Melsew Getaneh, Tamirat Hailegebriel, Abaineh Munshea and Endalkachew Nibret, Journal of Parasitology Research

The present study showed that STHs were common among schoolchildren around Lake Tana. Therefore, education on personal and environmental hygiene should be taken into account to reduce the prevalence of STH infection in the study area.

Soil-Transmitted Helminthiasis

Prevalence of intestinal parasitic infections and genetic differentiation of Strongyloides stercoralis among migrant workers from Myanmar, Lao PDR and Cambodia in northeastern Thailand

Wararat Sangwalee et al., PLOS One

Our findings provided molecular confirmation of the presence of Sstercoralis and explored the genetic differentiation of Sstercoralis from those infected migrant workers. An effective anti-parasitic drug should be provided for migrant workers and its administration enforced.

Infection of Soil-Transmitted Helminth among Mining Workers in Southeast Sulawesi

Yunita Amraeni, Muhammad Nirwan and Jumintono Suwardi, Al-Sihah : Public Health Science Journal

This study aims to know the intensity and prevalence of STH infections among mining workers by comparing fecal and nail examinations in Morindino Village, Kambowa District, North Buton Regency Southeast Sulawesi Province


Disability inclusion and community engagement: lessons from trachoma

Adugna Amin, Juliana Amanyi-Enegela, Faizah Tosin Okunade and Tim Jesudason, International Trachoma Control Initiative

Understanding the needs of people with disabilities, and the barriers they face, is an essential first step towards ensuring they are included in eye health services, including trachoma elimination programmes.

Factors influencing the prevalence of active trachoma in children aged one to nine years in Buyengo sub county Jinja district Uganda. A cross-sectional Study

Norman Ndikuno, Student's Journal of Health Research Africa

The prevalence of active trachoma is low (1.3%) in the Buyengo sub-county with the following associated factors Unclean face of the child, Not washing the face with soap, not having a latrine, and availability of flies in the child’s face.

Towards global elimination of Trachoma: An evaluation of Trachoma surveillance system, Wa East District, Ghana

Ernest Akyereko et al., Journal of Interventional Epidemiology and Public Health

The trachoma surveillance system is simple, useful, sensitive, and partially meeting its objectives. However, data quality needs improvement.

Chlamydia trachomatis: The Long Road to Describe Its Association with Disease in the Amazon Region of Brazil

Ricardo Ishak et al., BioMed

Long-term investigations among urban and nonurban populations are discussed and show the need for and effects of continuous surveillance to diminish the burden among vulnerable populations (female sex workers, quilombos and indigenous peoples) and to define new etiological associations of diseases with infections by C. trachomatis.


Application Open: The Falcon Awards for Disease Elimination

The Global Institute for Disease Elimination

The Global Institute for Disease Elimination (GLIDE) is launching a second iteration of the awards in January 2023, the Falcon Awards for Disease Elimination – The Climate Edit – a global initiative which aims to expand the evidence base regarding the intersection of disease elimination and climate. Through the awards, GLIDE will provide catalytic support to researchers to examine new and under-explored areas of the climate and infectious disease nexus.

In memoriam: Female trailblazers who leapt over barriers to fight for their sisters

Joanne Silberner and Laurel Dalrymple, Cap Radio

Mwele Ntuli Malecela: 'She made it her mission to empower ... African women scientists'

Design and evaluation of two educational media in the form of animation and games to promote the cutaneous leishmaniasis prevention behaviors in adolescent female

Masoumeh Alidosti, Hossein Shahnazi, Zahra Heidari and Fereshteh Zamani Alavijeh, BMC Public Health

The results showed that if educational programs contain a combination of threat and efficiency messages, CL-preventive behaviors in adolescents increase. Providing similar educational content with both game and animation methods indicated that both methods had an almost same effect. Although animation production is more costly, it has the advantage of being used in periods and for other adolescents.

The Democratic Republic of the Congo certified free of dracunculiasis transmission by WHO

World Health Organization

The World Health Organization (WHO) is proud to announce that it has certified the Democratic Republic of the Congo (DRC) as free of transmission of Dracunculus medinensis, the parasite that causes dracunculiasis (Guinea-worm disease).

Outputs from the 2022 COR-NTD Meeting


The 2022 annual meeting of the Coalition for Operational Research on Neglected Tropical Diseases (COR-NTD) was held virtually in October 2022. Content on this page captures the key discussion points, knowledge gaps, and recommended next steps identified by the participants from most of the 15 breakout sessions held at that event. 

Synthesis, Characterization, and Activity of Hydroxymethylnitrofurazone Nanocrystals against Trypanosoma cruzi and Leishmania spp.

Cauê Benito Scarim et al., Drug and Drug Candidates

The results showed that the optimized particle size of 108.2 ± 0.8 nm (NFOH-F1) and 132.4 ± 2.3 nm (NFOH-F2) increased the saturation solubility and dissolution rate of the nanocrystals. These formulations exhibited moderate anti-Leishmania effects (Leishmania amazonensis) in vitro and potent in vitro activity against T. cruzi parasites (Y strain). Moreover, both formulations could reduce parasitemia (around 89–95% during the parasitemic peak) in a short animal model trial (Y strain from T. cruzi). These results suggested that the increased water solubility of the NFOH nanocrystals improved their activity against Chagas disease in both in vitro and in vivo assays.

Eliminating Existing Epidemics: Investing in neglected tropical diseases strengthens our ability to fight global pandemics

Thoko Elphick-Pooley et al., The Forum Network

COVID-19 has shown us that our investments in fighting NTDs not only improve the quality of life of millions of people, they also can have an incredible impact on boosting global health security. 

Call for Applications: The Mwele Malecela Mentorship Program 2023 for Women in Neglected Tropical Diseases

Opportunities for Africans

The Mwele Malecela Mentorship Program for Women in Neglected Tropical Diseases supports mid-career African women to become leaders and champions in NTD elimination. Application deadline: Jan. 15, 2023.

A compendium of indicators for monitoring and evaluating progress of the road map for neglected tropical diseases 2021–2030

World Health Organization

This Compendium of indicators for monitoring and evaluating progress of the road map for neglected tropical diseases 2021–2030 complements the companion document to the road map entitled Ending the neglect to attain the Sustainable Development Goals: a framework for monitoring and evaluating progress of the road map for neglected tropical diseases 2021–2030 (“the M&E framework”).

Call for public consultation: Qualitative assessment of dimensions of the road map for neglected tropical diseases

World Health Organization

The WHO Secretariat is leading the follow-up assessment of the four priority dimensions of the heat map through the GAT, a qualitative, participatory device for tracking progress towards the 2030 targets of the road map. This public consultation seeks your perceptions on the status of progress along these four dimensions for all 20 NTDs. Your inputs will be consolidated for consideration by disease-specific focus groups whose deliberations will identify current gaps that pose a persistent risk to the attainment of the road map targets. This will provide qualitative evidence on corrective measures needed to address these gaps and inform reporting on global progress against NTDs to the Seventy-sixth World Health Assembly in 2024.