This news roundup is a collection of headlines and other items on neglected tropical diseases, and does not reflect the work or the views of the Coalition for Operational Research on Neglected Tropical Diseases or the Neglected Tropical Diseases Support Center.
Photo: Trypanosomiasis, human African (sleeping sickness); WHO
Photo credit: MSF/C. Mahoudeau
Bma-LAD-2, an Intestinal Cell Adhesion Protein, as a Potential Therapeutic Target for Lymphatic Filariasis
These results indicate that Bma-LAD-2 is an essential protein for adult Brugia malayi and may be an effective therapeutic target.
Ethiopia could be free of a disabling parasitic infection in as little as three years with the help of a UAE-led initiative. . . He [Seife] was speaking at an event in Abu Dhabi on Tuesday to announce a significant funding boost for RLMF [Reaching the Last Mile], a $22.5-million-dollar investment over the next three years by The Leona M. and Harry B. Helmsley Charitable Trust.
High infection rates for onchocerciasis and soil-transmitted helminthiasis in children under five not receiving preventive chemotherapy: a bottleneck to elimination
This study reveals that children < 5 years of age are highly infected with STH and onchocerciasis, and could contribute to the spread of these diseases, perpetuating a vicious circle of transmission and hampering elimination efforts.
At least 1.8 million received free oral treatment for schistosomiasis (bilharzia) and soil transmitted helminthiasis (intestinal worms) during a mass treatment exercise conducted from 3-9 April 2022.
An Update on Schistosomiasis: Prevalence, Intensity of Infection and Risk Factors among School-Aged Children in Njombe, Littoral Region, Cameroon
There was a drastic decline in the prevalence of schistosomiasis infection in schoolchildren in Njombé compared to previous reports. The decrease is attributed to the bi-annual deworming campaign by the Public Health Authorities.
Impact of Anthelmintic Treatment on the Burden of Helminth Infections in Primary Schoolchildren in Biyela Health Zone in Kinshasa, Democratic Republic of the Congo
These ﬁndings suggest that anthelminthic treatment reduces signiﬁcantly the prevalence of helminth infections. There was no impact on anaemia and Hb level due to the use of anthelmintic drugs.
Parasitic worm (helminth) infections are often described as a cause of stunting in children. However, a variety of factors can contribute to childhood stunting. Our recent systematic review found a lack of data to support this causative nexus and highlights the need for more research on this topic, particularly to recognise the role of maternal health and possible in utero stunting.
Prevalence of Trachoma from 66 Impact Surveys in 52 Woredas of Southern Nations, Nationalities and Peoples’ and Sidama Regions of Ethiopia, 2017–2019
Based on the findings, further antibiotic mass drug administration is required in 37 woredas and active TT case finding is needed in 40 woredas. In these surveys, access to WASH facilities was very low; WASH improvements are required.
A national survey integrating clinical, laboratory, and WASH data to determine the typology of trachoma in Nauru
TF, nucleic acid, and age-specific antibody prevalence collectively indicate that high levels of C. trachomatis transmission among children present a high risk of ocular damage due to trachoma. The absence of trichiasis with trachomatous scarring suggest a relatively recent increase in transmission intensity.
Productivity, efficiency and gender equity of community mobilisation approaches in trichiasis campaigns: analysis of programmatic data from seven sub-Saharan African countries
In these settings, house-to-house case finding appears to be a more effective and efficient approach to ensure that trichiasis cases, particularly in women, obtain access to surgical services.
Colorimetric and Real-Time Loop-Mediated Isothermal Amplification (LAMP) for Detection of Loa loa DNA in Human Blood Samples
Our Loa loa-LAMP could be a promising molecular tool for the easy, rapid and accurate screening of patients for loiasis in endemic areas with low-resource settings. The real-time testing (feasible in a handheld device) could be very useful to rule out high-microfilariae loads in infected patients.
The non-profit Drugs for Neglected Diseases Initiative (DNDi)is funding a trial of rapid tests in Santiago del Estero. . . DNDi has also been running clinical trials of shortened treatment regimens with benznidazole, though with relatively small samples thus far. While benznidazole is an imperfect tool to fight Chagas, it’s the best one currently available, so at least reducing the treatment period from two months to two weeks can make it easier to handle any side effects.
The University of Dundee’s Wellcome Centre for Anti-Infectives Research (WCAIR) has received more than £5 million from the Wellcome Trust to advance its world-leading research into neglected tropical diseases.
The @WHO validated #Rwanda on 26 April 2022 for having eliminated Human African Trypanosomiasis #HAT (commonly known as Sleeping Sickness) as a Public Health problem.
Congratulations to Rwanda! The WHO validated Rwanda on 26 April, 2022, for having eliminated Human African Trypanosomiasis #HAT (commonly known as Sleeping Sickness) as a Public Health problem.
Ministry of Health, Malaysia and Drugs for Neglected Diseases initiative combine forces to lead the battle against dengue
Malaysian Ministry of Health through Clinical Research Malaysia (CRM) today joined forces with the international non-profit medical research organization Drugs for Neglected Diseases initiative (DNDi) in a collaboration that aims to develop safe, affordable, and effective treatments for dengue fever.
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Training Course: Parasite Genetics of Neglected Tropical Diseases
May 9-13, 2022
TrypanoGEN+ consortium, Makerere University, Uganda Virus Research Institute, Africa Centre of Excellence for Neglected Tropical Diseases and Forensic Biotechnology
Diagnosis of schistosomiasis by CCA or CAA detecting lateral flow tests: Facts and challenges.
June 14, 2022
Global Schistosomiasis Alliance
47th Annual Topics in Infection
June 17, 2022
RSTMH, Barts Health and UKHSA
Worldleish7 (the international Congress on leishmaniasis)
Aug. 1-6, 2022
2022 COR-NTD Annual Meeting
October 4-5, 2022
Coalition for Operational Research on Neglected Tropical Diseases
2022 ASTMH Annual Meeting
October 30-November 3, 2022
American Society of Tropical Medicine & Hygiene
21st International Leprosy Congress 2022
November 8-10, 2022