New Target Product Profiles and Other NTD News

This news roundup is a collection of headlines and other items on neglected tropical diseases, and does not reflect the work or the views of the Coalition for Operational Research on Neglected Tropical Diseases or the Neglected Tropical Diseases Support Center.


Photo: A strategic framework for the integrated control and management of skin NTDs-Webinar Launch June 8; Credit: WHO
Control, Elimination and Eradication of the skin Neglected Tropical Diseases


Lymphatic filariasis

DOLF Team receives a $1.8 million Bill and Melinda Gates Foundation Grant to Explore Lymphatic Filariasis Elimination in Indonesia

Peter Fischer and Gary J. Weil, Washington University School of Medicine in St. Louis

As a result, the Ministry of Health is seeking to determine why LF returned and will conduct two more rounds of MDA in the fall of 2022 and 2023. For this resumed MDA, triple drug treatment with ivermectin combined with DEC and albendazole (IDA) will be used that was developed a few years ago by DOLF.

Safety and Tolerability of Ivermectin and Albendazole Mass Drug Administration in Lymphatic Filariasis Endemic Communities of Tanzania: A Cohort Event Monitoring Study

Adam M. Fimbo et al., Pharmaceuticals

A chronic illness, or clinical manifestation of lymphatic filariasis, or being female or pre-existing clinical symptoms were independent significant predictors of AEs. IA combination preventive chemotherapy is safe and tolerable, and associated AEs are mild-to-moderate and transient, with few severe AEs. Safety monitoring during MDA campaigns in individuals with underlying clinical conditions is recommended for timely detection and management of AEs.

Mass drug administration for elimination of Lymphatic Filariasis

Litia Cava, FBC News (Fiji)

Waqainabete says with COVID19 restrictions now being lifted and good coverage of the COVID 19 vaccination rate, the Lymphatic Filariasis program has finally been able to roll out the second round of MDA in the coming days.

8% of world population at risk of filaria lives in UP

Shailvee Sharda, Times of India

The drive will be launched virtually by deputy CM and health minister Brajesh Pathak on Thursday. Dr Singh said that 19 districts were being covered in the present round.

Mosquito Species To Be Listed As Restricted Animals

Big Island Video News (USA)

HONOLULU, Hawaiʻi -The State plans to introduce mosquitos containing the Wolbachia bacterium in order to reduce mosquito populations and thus "reduce the potential of transmission of mosquito vectored diseases.

Mass drug administration of ivermectin, diethylcarbamazine, plus albendazole compared with diethylcarbamazine plus albendazole for reduction of lymphatic filariasis endemicity in Papua New Guinea: a cluster-randomised trial

Moses Laman et al., The Lancet Infectious Diseases

Mass administration of the triple-drug regimen was more effective than the two-drug regimen in reducing microfilariae prevalence in communities to less than the target level of 1%, but did not reduce circulating filarial antigen prevalence to less than 2%. These results support the use of mass drug administration with the triple-drug regimen to accelerate elimination of lymphatic filariasis.


Unbalanced relationships: insights into the interaction between gut microbiota, geohelminths, and schistosomiasis

Matheus Pereira de Araújo et al., Peer J

Thus, this work aimed to understand interactions between the microbiota and parasitic diseases caused by the most important geohelminths and schistosomiasis and the consequences of these associations.

Using choice modelling to identify popular and affordable alternative interventions for schistosomiasis in Uganda

Keila Meginnis et al., Cambridge University Press

We administered a discrete choice experiment to understand community preferences for interventions that would reduce individuals' risk of contracting, or transmitting, Schistosoma mansoni. These focused on water access, sanitation and hygiene (WASH) interventions. We compared interventions that target behaviours that mainly put oneself at higher risk versus behaviours that mainly put others at risk. We used two payment vehicles to quantify what individuals are willing to give up in time and/or labour for interventions to be implemented. Key findings indicate that new sources of potable water and fines on open defecation are the highest valued interventions.

The Road to Elimination: Current State of Schistosomiasis Research and Progress Towards the End Game

Paul Ogongo, Ruth K. Nyakundi, Gerald K. Chege and Lucy Ochola, Frontiers in Immunology

To date, control strategies have focused on effective diagnostics, mass drug administration, complementary and integrative public health interventions. Non-mammalian intermediate hosts and other vertebrates promote transmission of schistosomiasis and have been utilized as experimental model systems. Experimental animal models that recapitulate schistosomiasis immunology, disease progression, and pathology observed in humans are important in testing and validation of control interventions. We discuss the pivotal value of these models in contributing to elimination of schistosomiasis. 

Soil-Transmitted Helminthiasis

The Use of MALDI-TOF MS as a Diagnostic Tool for Adult Trichuris Species

Julia Rivero, Antonio Zurita, Cristina Cutillas and Rocío Callejón, Frontiers in Veterinary Science

The use of matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS) is increasing since the last decades due to its recent evidence as a potential role for reliable identification of microorganisms and a few nematodes. . .The results confirmed that MALDI-TOF MS was able to identify Trichuris species. Additionally, a MALDI-TOF MS profile of T. suis proteome was carried out to develop the first internal database of spectra for the diagnosis of trichuriasis and other Trichuris spp.

The first report on the prevalence of soil-transmitted helminth infections and associated risk factors among traditional pig farmers in Bali Province, Indonesia

Kadek Karang Agustina, I. Made Ady Wirawan, I. Made Sudarmaja, Made Subrata and Nyoman Sadra Dharmawan, Veterinary World

The infections seen in farmers were distributed among hookworm, Ascaris spp., and Trichuris spp., at 15.1%, 9.2%, and 4.2%, respectively. The risk factors associated with infections of STH and Ascaris spp. were personal hygiene, home sanitation, education level, household income, and having a primary occupation as a traditional pig farmer. In contrast, personal hygiene, education level, and primary occupation were the only risk factors for hookworm infection, while personal hygiene and home sanitation were the risk factors associated with Trichuris spp. infection. The limitation of this study was that the number of samples was relatively small due to the difficulty of obtaining stool samples from traditional pig farmers, with many individuals refusing to provide their stool for inspection. 

Prevalence of Intestinal Parasite Infections and Associated Factors among Pregnant Women in Northwest Ethiopia

Yibeltal Aschale, Awoke Minwuyelet, Tadesse Yirga Akalu and Asmare Talie, Journal of Parasitology Research

Intestinal parasite infections remained a serious health burden to pregnant women in the study area with the dominance of a hematophagous worm (hookworm). Community-based intestinal parasite screening and treatment are essential to alleviate the burden caused by intestinal parasite infections.


Arboviral disease record data - Dengue and Chikungunya, Brazil, 2013–2020

Sebastião Rogério da Silva Neto et al., Scientific Data

The data presented in this work will assist researchers in investigating antecedents of arbovirus emergence and transmission more generally, and Dengue and Chikungunya in particular. Furthermore, it can be used to train and test machine learning models for differential diagnosis and multi-class classification.

Lobomycosis Epidemiology and Management: The Quest for a Cure for the Most Neglected of Neglected Tropical Diseases

Franciely G. Gonçalves et al., Journal of Fungi

An effective therapy for lobomycosis has been found following decades of research led by the State Dermatology Program of Acre in the Amazon rainforest, where the largest number of cases occur. This discovery opened new avenues for future studies. The main recommendations here, addressed to the Brazilian Ministry of Health, are for lobomycosis to become a reportable disease to ensure that disease prevalence is measured, and that it be prioritized such that affected individuals may access treatment free-of-charge.


World Health Organization

TARGET PRODUCT PROFILE for a rapid test for diagnosis of Buruli ulcer at the primary health-care level

TARGET PRODUCT PROFILE - Dermal Leishmaniases

World Health Organization

TARGET PRODUCT PROFILE for a point-of-care diagnostic test for dermal leishmaniases


World Health Organization

TARGET PRODUCT PROFILE for the detection of a case of yaws and the detection of azithromycin resistance


World Health Organization

TARGET PRODUCT PROFILE for scabies to start and stop mass drug administration


World Health Organization

TARGET PRODUCT PROFILE for a rapid test for diagnosis of mycetoma at the primary health-care level

Nigeria gets second Noma treatment centre

Fred Ezeh, The Sun (Nigeria)

A second treatment centre for Noma, one of the Neglected Tropical Diseases (NTD) in Nigeria, is being built at the National Hospital, Abuja, to serve the needs of patients who require the services.


Leaving no one behind: targeting mobile and migrant populations with health interventions for disease elimination—a descriptive systematic review

Molly W Adams, Elizabeth G Sutherland, Erin L Eckert, Khalida Saalim and Richard Reithinger, BMC Medicine

Ultimately, the literature reviewed here can inform programmatic decisions as the community attempts to reach these never treated populations.


NOTE - Events may be postponed or cancelled due to the COVID-19 pandemic. Please check with event organizers to confirm events. 

Elimination of Leprosy: Initiatives in the Americas and Africa
June 7, 2022
Sasakawa Health Foundation

A strategic framework for the integrated control and management of skin NTDs – Launch webinar
June 8, 2022
World Health Organization

Diagnosis of schistosomiasis by CCA or CAA detecting lateral flow tests: Facts and challenges.
June 14, 2022
Global Schistosomiasis Alliance

47th Annual Topics in Infection
June 17, 2022
RSTMH, Barts Health and UKHSA

Kigali Summit on Malaria and Neglected Tropical Diseases
June 23, 2022
Government of Rwanda 

Worldleish7 (the international Congress on leishmaniasis)
Aug. 1-6, 2022

11th International Conference on Emerging Infectious Diseases (ICEID)
Aug. 7-10, 2022
Centers for Disease Control and Prevention

2022 NNN Conference
Sept. 13-15, 2022
Neglected Tropical Disease NGO Network

2022 COR-NTD Annual Meeting
October 4-5, 2022
Coalition for Operational Research on Neglected Tropical Diseases

The 20th International Congress for Tropical Medicine and Malaria (ICTMM)
October 24 - 28, 2022
MESA Alliance 

2022 ASTMH Annual Meeting
October 30-November 3, 2022
American Society of Tropical Medicine & Hygiene 

21st International Leprosy Congress 2022
November 8-10, 2022