WHO announces standard operating procedures for supply chain management and other NTD News

This news roundup is a collection of headlines and other items on neglected tropical diseases, and does not reflect the work or the views of the Coalition for Operational Research on Neglected Tropical Diseases or the Neglected Tropical Diseases Support Center.


Photo: From Zero to 100: How Integration of Gender Equity and Social Inclusion Helps Reach Ugandan Communities with NTD Treatment; Photo credit: RTI International/Conrad Roy

Lymphatic filariasis

Harnessing Immune Evasion Strategy of Lymphatic Filariae: A Therapeutic Approach against Inflammatory and Infective Pathology

Priyanka Bhoj, Namdev Togre, Vishal Khatri and Kalyan Goswami, Vaccines

This paper reviews immunomodulatory mechanisms acquired by these filariae for their own survival and their potential application in the development of novel therapeutic approaches against parasitic and inflammatory diseases. Insight into the intricate network of host immune-parasite interactions would aid in the development of effective immune-therapeutic options for both infectious and immune-pathological diseases.


Evaluation of mass treatment with ivermectin program reach and survey coverage for onchocerciasis elimination in selected endemic areas of Ethiopia

Gebremedhin Gebrezgabiher, Delenasaw Yewhalaw, Asrat Hailu and Zeleke Mekonnen, PLOS One

This study was thus conducted with the purpose of i) providing estimate of ivermectin coverage, ii) validating the MDA coverage reported through community drug distributors (CDDs), iii) determining the factors associated with MDA coverage, and iv) estimating the difference between MDA program reach and survey coverage rates following MDA campaign carried out in May 2017 in Asosa and Yeki districts in Ethiopia. 


Prevalence and Molecular Characterization of Dral 1 gene of Schistosoma haematobium Associated with Pathogenesis of Human Urinary Schistosomiasis among School Pupils in Cross River State, Nigeria

Chinyere Osondu-Anyanwu, Imalele E. Edema, Nkoyo Ani Nkang, Jenavine Onyinye Mbah and Godwin M. Ubi, Annual Research & Review in Biology

This study evaluates the prevalence of Schistosoma haematobiuminfection  among school aged children in Biase, Obubra and Ogoja Local Government Areas of Cross River State. . . This study therefore, revealed a critical need for targeting health campaign towards school age children and heads of households in order to empower them with the basic knowledge to recognize, treat and manage their health challenges.Applications of one to two doses of praziquantel considerably reduced the severity of urinary Schistosomiasis in the study area.

Stakeholders’ Perspectives on the Application of New Diagnostic Devices for Urinary Schistosomiasis in Oyo State, Nigeria: A Q-Methodology Approach

Karlheinz Tondo Samenjo et al., Global Health: Science and Practice
  • Q-methodology served as a rigorous tool to identify the needs and product-service design requirements of stakeholders throughout the health care system.

  • Stakeholders at various levels of the health care system shared that new diagnostic devices for schistosomiasis should: be available at the point of need and require minimal infrastructure to increase diagnostic capacity and surveillance, particularly in rural or distant settings; be less expensive to make diagnostic testing more affordable; and be able to identify infection status before treatment to support the identification and prioritization of patients or areas in need of treatment.

Soil-Transmitted Helminthiasis

Comparison of Human Intestinal Parasite Ova Segmentation Using Machine Learning and Deep Learning Techniques

Chee Chin Lim et al., Applied Sciences

[This] paper aims to compare the human intestinal parasite ova segmentation performance between machine learning segmentation and deep learning segmentation. . . Therefore, segmentation through deep learning is more suitable for segmenting the human intestinal parasite ova.

N-(4-Methoxyphenyl)Pentanamide, a Simplified Derivative of Albendazole, Displays Anthelmintic Properties against the Nematode Toxocara canis

Taís C. Silva et al., Microbiology Spectrum

Collectively, the results of this study demonstrate that the molecular simplification of albendazole to give N-(4-methoxyphenyl)pentanamide may be an important pipeline in the discovery of novel anthelmintic agents.

Phase 3 of the ALIVE trial is Well Underway!

Stopping Transmission of Intestinal Parasites

The ALIVE trial aims to test the safety and efficacy of combining a fixed dose of ivermectin and albendazole in one single pill, compared to the current treatment (albendazole alone), for the treatment of intestinal worms (soil-transmitted helminths). If successful, this new combination would represent an important tool for programmes aimed at interrupting transmission of STH, and would also help prevent the emergence of drug-resistant worms.


From Zero to 100: How Integration of Gender Equity and Social Inclusion Helps Reach Ugandan Communities with NTD Treatment

Mike Mukirane Biregho, Emmanuel Ssegawa and Claire Karlsson, RTI International

The analysis sought to understand what factors related to gender, disability, or social status might be hindering people from receiving NTD medicines. As part of this analysis, Moroto citizens joined focus groups to discuss their knowledge of NTDs, their access to treatment, the reasons they might not want to take the medicines, and how trachoma impacted their lives and their families. The results of the analysis indicated that gender and social inclusion barriers impacted exposure to infection, and influenced access to and uptake of NTD services, including during mass treatment campaigns in Moroto.


Special Issue: Sustainable Vector Biology Research Systems in Africa

Medical and Veterinary Entomology

[This special issue highlights] the need for African researchers to lead the way in vector biology research, and highlighting the great work being done in this area. 

Standard operating procedures for supply chain management of health products for neglected tropical diseases amenable to preventive chemotherapy

World Health Organization

WHO and the NTD Supply Chain Forum prepared this set of standard operating procedures to reflect key characteristics in the supply chain management of health products including donated medicines for use in mass drug administration (MDA) at the country level. Health ministries and national programmes for NTDs are encouraged to adopt and adapt them to their country context.


Sightsavers Decries Poor Access to Opthalmologists in Rural Areas

Ashe News (Nigeria)

Isiyaku, while stressing the need to improve access to health care services in the rural areas and for People with Disabilities (PWDs), urged the media to highlights their challenges to attract action towards resolving them.

The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era

Emma Taylor et al., International Health

The Amazonian Tropical Bites Research Initiative (ATBRI) has been created, with the aim of creating transdisciplinary solutions to the problem of animal bites leading to disease in Amazonian communities. The ATBRI seeks to unify the currently disjointed approach to the control of bite-related neglected zoonoses across Latin America.

Dengue surge in Bangladesh’s Rohingya camps results in over 7,600 cases

La Prensa Latina Bilingual Media

Bangladesh authorities on Monday reported that over 7,600 dengue cases, including four deaths, had been registered among Rohingya refugees this year, even as experts warned that the situation could escalate dangerously if measures are not taken quickly.

Better testing boosts leprosy response in the Democratic Republic of the Congo

Eugene Kabambi and Collins Boakye-Agyemang, World Health Organization

Sasakawa Foundation support helped train 720 community teams to conduct awareness-raising activities. In addition, 54 teams and 180 nurses from various health zones learned to identify early symptoms and examine community contact cases.

“We can raise awareness in churches, schools, markets, and in the streets with loudspeakers, as well as through community radio stations,” says Dr Florent Ngondu, Director of the programme for the elimination of leprosy at the Ministry of Health. “It has triggered not only a surge of presumed cases among which leprosy has been detected, but also cases of scabies, mycosis, vitiligo and other skin afflictions.”


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