Swiss Tropical and Public Health Institute (Swiss TPH)
Schistosoma Prevalence in Mekong River Basin of Cambodia and Laos Border
Determine the Schistosoma prevalence in the Mekong River Basin on the border of Laos and Cambodia
This study will include comparing 1) MDA as usual 2) double treatment with two closely-spaced MDAs (consistent with the recommendation based on mathematical models) 3) twice yearly MDA and 4) double MDA plus snail control.
Sustaining schistosomiasis control in Cote D'Ivoire and Kenya
MDA strategies: Sustaining control at 10 – 24% prevalence
(1) Is it possible to eliminate schistosomiasis as a public health problem on Unguja in three years and to interrupt transmission in five years? (2) Is it possible to control schistosomiasis throughout Pemba (prevalence <10%) in three years and to eliminate it as a public health problem in five years? (3) What are the costs, successful strategies, barriers, etc. associated with three different interventions (MDA, vector control, and behavior change)?
POC/CCA screening/mapping tool initial Studies
Characterising the spatial distribution of schistosomiasis prevalence in school-age children to develop optimal survey designs for informing sub-implementation unit decisions (Cote d'Ivoire)
The primary research question for the field work in Cote d'Ivoire is: what is the fine scale prevalence of S. haematobium and S. mansoni in 3 districts among children 5-14 years old?
Single vs. multiple treatments of praziquantel in intestinal African schistosomiasis: a randomized, double-blind, placebo controlled trial investigation using new diagnostic tools
Rigorous assessment of the efficacy of (multiple) doses with Praziquantel in the treatment of S. mansoni infections using standard and novel highly sensitive diagnostic tools.
The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions.
The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. Research methods include: (1) stakeholder mapping and network analysis, (2) qualitative research, (3) structural readiness surveys, (4) process mapping, and (5) economic evaluation (costing and cost-effectiveness).
Implementation science research aims include:
1)To systematically identify stakeholders influencing standard of care targeted and community-wide MDA and map their potential role and involvement in scale-up of community-wide MDA for STH.
2)To identify implementation-related barriers and facilitators to community-wide MDA for STH from the perspective of various stakeholders.
3)To quantify the readiness of the health system to deliver community-wide MDA for STH programs.
4)To map the intervention delivery process and identify any discrepancies between planned and implemented activities in order to optimize the trial intervention.
5)To compare the financial and economic costs and incremental cost-effectiveness of community-wide and targeted MDA for STH in the short- and long-term.
Characterizing the spatial distribution of schistosomiasis prevalence in school age children to develop the optimal survey designs for sub-implementation unit decisions
What is the optimal sampling strategy for SCH impact assessments to enable sub-implementation unit decisions?
Characterising the spatial distribution of schistosomiasis prevalence in school-age children, following ≥5 rounds of preventive chemotherapy, to develop optimal survey designs for informing sub-implementation unit decisions
How is the epidemiological distribution of Schistosoma haematobium in school aged children (5 to 14 years) after multiple rounds of preventive chemotherapy across three districts in Togo.
Can the Schistosoma haematobium Recombinase Polymerase Amplification (Sh-RPA) assay be optimized for field use to support monitoring and evaluation of Schistosomiasis control programs?