University of Georgia
Identifying schistosomiasis genetic markers in Brazil
Develop genetic markers for S. haematobium
Multi-country perspective on mobile data collection
SCORE Data Collection on Mobile Devises
Evaluation of the Short Term Impact of MDA on Prevalence and Intensity
The purpose of this study is to determine differences between cure rates vs re-infection levels. The fundamental question is to see what the prevalence and intensity are before MDA, and then, see what those are 7 to 8 weeks after MDA. Since there are villages that continue to have high prevalence from year to year, we will determine if this primarily represents reinfection occurring since the last annual MDA or if it is related more to treatment efficacy.
Persistent Hot Spots for Schistosoma mansoni Transmission in Western Kenya
A selected number of 5 villages near Lake Victoria shown to maintain very high levels of infection with S. mansoni following at least three rounds of annual praziquantel chemotherapy will be compared with 5 villages where infection rates have been much more responsive to similar levels of treatment, with respect to the following general considerations and questions:
1) What is the general situation for each village with respect to proximity of water bodies where intensive human contact occurs?
2) For each village, what is the role of each major habitat in transmission, as assessed by three separate techniques: water filtration; use of sentinel mice; and standard snail survey techniques?
Development of Mobile Reader Application at Point-of-care for POC-CCA
Develop a mobile reader application for use at the point-of care for the POC-CCA assay used for mapping and surveillance of Schistosoma mansoni. The reader apk will provide results consistent with the visual human reading of the test. Distinguishing intensity bands and reading 'Trace' results can be problematic and leads commonly to 'false positive' readings. The apk being developed will utilize a testing algorithm to better distinguish between true positive and false positive "Trace" test results.
Identifying CCA testing standards in Kenya
POC/CCA tool ongoing studies: Use of testing standards; reader differences; ‘Trace’ result analyses
What is the the impact of riverine prawns on infections in humans? Studies are to be conducted on interrupting seasonal transmission of Schistosomiasis and ecologic assessment of riverine prawns on infections in humans.
Analysis of schistosomiasis diagnostics
Human Diagnostics Tool Development (CAA diagnostic tool)
Cost-effectiveness analysis of schistosomiasis control
Cost Studies in SCORE Gaining and Sustaining
Schistosomiasis population genetics in Niger and Tanzania
Schistosome Population Genetics in Gaining Control Studies in Niger (Sh) and Tanzania (Sm)
Comparison of CCA and PCR
Screening Tool POC/CCA: PCR comparative studies
Snail control in Niger and Tanzania
Part of gaining control studies
Rapid Answer Projects (RAPs)
Literature review, meta-analyses; 3 RAPs published; one RAP white paper; see SCORE website http://score.uga.edu/projects/rapid-answers-project/
Elimination of S. haematobium in Seasonal Transmission Sites
This study will include comparing 1) MDA as usual 2) double treatment with two closely-spaced MDAs (consistent with the recommendation based on mathematical models) 3) twice yearly MDA and 4) double MDA plus snail control.
Mapping of Schistosomiasis in Rwanda and Burundi
Mapping of schistosomiasis (Sm)
Gaining schistosomiasis control in Kenya, Mozambique, and Tanzania
Gaining Control: >25% Prevalence MDA strategies; and subtle morbidity of Cohort; Population genetics, and snail monitoring
Sustaining schistosomiasis control in Cote D'Ivoire and Kenya
MDA strategies: Sustaining control at 10 – 24% prevalence
Sustaining and gaining schistosomiasis control in Niger
Sustaining / Gaining Control with Single versus Double Treatment; and Population genetics, snail monitoring
Schistosomiasis elimination in Zanzibar
(1) Is it possible to eliminate schistosomiasis as a public health problem on Unguja in three years and to interrupt transmission in five years? (2) Is it possible to control schistosomiasis throughout Pemba (prevalence <10%) in three years and to eliminate it as a public health problem in five years? (3) What are the costs, successful strategies, barriers, etc. associated with three different interventions (MDA, vector control, and behavior change)?
Interventions in Persistent Hot-Spots in Tanzania
How do villages which do not show substantial decreases in the prevalence of schistosomiasis despite repeated, high coverage mass drug administration (persistent hot-spot villages) differ from villages which show substantial decrease in prevalence across various factors (declining prevalence villages)?
Is molecular detection of schistosome infection (patent and pre-patent) in snails a useful tool for program managers as prevalence and intensity of infection in people approaches very low levels?
Economic analysis in SCORE projects
Economic evaluation of SCORE projects with priority given to elimination studies
Interventions in Persistent Hot-Spots in Kenya
Will providing enhanced MDA at the community level while achieving treatment coverage of 75% or greater in children (5-17) and adults substantially decrease S. mansoni infection in previously identified persistent hot-spot communities?
Cross-country analysis of CCA test for screening/mapping
POC/CCA screening/mapping tool initial Studies
Snail control in Kenya with 20 year follow-up
Snail Control follow-up study of P. clarkii 20 years later