Onchocerciasis LAMP assay to optimize diagnostics and sampling strategies for low-prevalence settings in Cameroon

Research question

 

1. Can the O-150 LAMP assay be established on whole blood? 2. Can the O-150 qPCR methodology be adapted for human sampling?

Secondary

1. How does the performance of the O-150 LAMP compare to the O-150 qPCR assay?

2. What threshold be used to define positive vs negative results for both assays?

3. Can deep sequencing reveal over potential biomarkers for further investigation?

 

 

Study sites

Notes

Sample size is inclusive of multiple phases.