The role of infection and antibody data for improved understanding of recrudescent active trachoma in Nebbi district of Uganda

To investigate the relationship between clinical signs of trachoma (TF), C. trachomatis infection and pgp3 antibody responses in EUs previously with recrudescent active trachoma.

1)To determine the prevalence of ocular Chlamydial infection and pgp3 serology among children aged 1 – 9 years in Nebbi East and Nebbi West EUs.

2)To determine if the Ct infection and serology data suggest ongoing transmission of trachoma within the EU. 

3)To investigate geographic, demographic, behavioral or WASH factors that are correlated with chlamydial infection, pgp3 and/or TF positivity that could inform more effective program interventions.